From Idea to
Anticancer Drug

THE PATH TO ONKONEK

Collaboration with colleagues at the University of Southampton resulted in a paper in 2011 which described the amino acid sequence PRGPRP.

Found in a previously unidentified part of the key molecule which starts cancer cell division, PRGPRP can, at high dose, selectively kill cancer cells but spare normal cells.

Hilmar Warenius

PRGPRP itself did not have high enough activity to work clinically.
Hilmar Warenius has now developed a lead agent with much higher activity which is suitable for clinical development.

THE BREAKTHROUGH

The discovery of PRGPRP in the NKR region of CDK4
the key molecule controlling cancer cell division*

STARTS CANCER GROWTH

Already well known

PREVENTS CANCER SUICIDE (APOPTOSIS)

Previously Unrecognised

* Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4. Hilmar M Warenius, Jeremy D Kilburn, Jon W Essex , Richard I Maurer, Jeremy P Blaydes, Usha Agarwala and Laurence A Seabra. Molecular Cancer 2011, 10:72

From Idea to Anticancer Drug